BSc PhD (Liverpool)
Professor of Imaging Neuroscience
- Associate Head of Department (IT/Information Governance)
- Associate Director & Head of Translation, OHBA
- Theme Lead, NIHR Oxford Health BRC (Older Adults & Dementia)
- NIHR Oxford BRC Principal Fellow
- Head, Translational Neuroimaging Group
My research focuses on using neuroimaging to understand risk for psychiatric and neurodegenerative disease.
By the time conditions such as Alzheimer’s Disease and Parkinson’s Disease are clinically diagnosed, much of the damage in the brain is already done. My group focuses on understanding mechanisms of risk, i.e. investigating how factors such as particular genes change brain structure and function before people are suffering from the symptoms of disease. We hope that, when neuroprotective agents become available, we will be able to identify individuals in whom these agents will be most effective.
My interest in brain imaging began at the Magnetic Resonance and Image Analysis Research Centre (MARIARC) at the University of Liverpool. I moved to Oxford as a post-doc in 2000, and alongside developing an independent research career I managed the neuroimaging ‘half’ of the Oxford Centre for Clinical Magnetic Resonance Research (OCMR). I lead the Translational Neuroimaging Group and am Associate Director of the Oxford Centre for Human Brain Activity (OHBA), which is part of the new Wellcome Centre for Integrative Neuroimaging. I lead the Older Adults & Dementia Theme for the NIHR Oxford Health Biomedical Research Centre, and the Imaging Informatics programme for the MRC Dementias Platform UK. I am also imaging lead for the Oxford Parkinson’s Disease Centre (OPDC), and the Whitehall II imaging study.
Predicting cognitive resilience from midlife lifestyle and multi-modal MRI: a 30-year prospective cohort study
TOPIWALA A. et al, (2019), PLoS ONE
Neuromelanin-MRI in REM sleep behaviour disorder predicts dopaminergic dysfunction and clinical risk of Parkinson's disease
Barber T. et al, (2018), MOVEMENT DISORDERS, 33, S79 - S79
Apathy in rapid eye movement sleep behaviour disorder is associated with serotonin depletion in the raphe nuclei
Barber T. et al, (2018), MOVEMENT DISORDERS, 33, S834 - S834
ZOKAEI N. et al, (2018), Neurobiology of Aging
O'Donoghue MC. et al, (2018), Cortex, 104, 103 - 123