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Although the ventromedial prefrontal cortex (vmPFC) has long been implicated in reward-guided decision making, its exact role in this process has remained an unresolved issue. Here we show that, in accordance with models of decision making, vmPFC concentrations of GABA and glutamate in human volunteers predict both behavioral performance and the dynamics of a neural value comparison signal. These data provide evidence for a neural competition mechanism in vmPFC that supports value-guided choice.

Original publication

DOI

10.1038/nn.3140

Type

Journal

Nat Neurosci

Publication Date

17/06/2012

Volume

15

Pages

960 - 961

Keywords

Adolescent, Adult, Brain Mapping, Choice Behavior, Humans, Inhibition (Psychology), Male, Prefrontal Cortex, Psychomotor Performance, Reward, Young Adult