Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Transcranial direct current stimulation (tDCS) modulates cortical excitability and is being used for human studies more frequently. Here we probe the underlying neuronal mechanisms by measuring polarity-specific changes in neurotransmitter concentrations using magnetic resonance spectroscopy (MRS). MRS provides evidence that excitatory (anodal) tDCS causes locally reduced GABA while inhibitory (cathodal) stimulation causes reduced glutamatergic neuronal activity with a highly correlated reduction in GABA, presumably due to the close biochemical relationship between the two neurotransmitters.

Original publication

DOI

10.1523/JNEUROSCI.4432-08.2009

Type

Journal article

Journal

J Neurosci

Publication Date

22/04/2009

Volume

29

Pages

5202 - 5206

Keywords

Adult, Brain Mapping, Cerebral Cortex, Female, Humans, Magnetic Resonance Spectroscopy, Male, Middle Aged, Neurotransmitter Agents, Transcranial Magnetic Stimulation, Young Adult