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A number of recent papers1-3 have demonstrated a relationship between in vivo concentration of GABA, as assessed using Magnetic Resonance Spectroscopy (MRS), and an individual's task performance, giving a unique insight into the relationship between physiology and behavior. However, interpretation of the functional significance of the MRS GABA measure is not straightforward. Here we discuss some of the outstanding questions as to how total concentration of GABA within a cortical region relates to phasic and tonic GABA activity within the cortical volume studied.

Original publication

DOI

10.4161/cib.4.5.16213

Type

Journal article

Journal

Commun Integr Biol

Publication Date

09/2011

Volume

4

Pages

573 - 575

Keywords

gamma-amino butyric acid (GABA), human, inter-individual differences, magnetic resonance spectroscopy, motor cortex