Carriers of the APOE e4-allele are at increased risk of developing Alzheimer's Disease. Mackay’s group have recently shown that APOE genotype is associated with brain function differences using fMRI in young healthy people. We will repeat this fMRI experiment with MEG to characterise the resulting differences in  neuronal signalling, and to harness more sophisticated time-dependent analyses of functional connectivity. (Funded by PhD studentship from the Alzheimer's Research and application to the Alzheimer’s Society.)